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Oleic Acid: The Secret Behind the Diet
2/6/2005 - Scientists have discovered one of the secrets behind the potent health benefits of the Mediterranean diet. It's actually in in the oil--olive oil. The key is oleic acid, the main component of olive oil.
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Oleic acid in particular is pretty effective in the fight against breast cancer, Dr Javier Menendez, of Northwestern University Feinberg School of Medicine in Chicago, said oleic acid blocks the action of a cancer-causing oncogene called HER-2/neu, which is found in about 30 percent of breast cancer patients.
Interestingly enough, olive oil is one of the better fats to consume on the Metabolic Diet which is so much like the Mediterranean diet in its emphasis on unsaturated fats as part of healthy eating. Oleic acid is one of the important monosaturated, polysaturated, and essential fatty acids incorporated in MD+ MRP LoCarb, a high protein/low carbohydrate/ moderate fat meal replacement powder.
In a series of laboratory experiments on breast cancer cell lines, the expression of the breast cancer gene Her-2/neu was cut by more than 46 percent when treated with oleic acid. Oleic acid was found not only to suppress the action of the oncogene, it also improved the effectiveness of the breast cancer drug Herceptin -- a targeted therapy that works against the Her-2/neu gene.
Breast cancer patients with Her-2/neu positive tumors suffer from an aggressive form of the disease and have a poor prognosis.
What oleic acid does to boost Herceptin is caused by DNA fragmentation, which promotes the death of cells that have amplified levels of Her-2/neu.
The study provides scientific evidence that dietary fatty acids can regulate the growth and spread of breast cancer cells.
References:
http://www.nlm.nih.gov/medlineplus/news/fullstory_22289.html
http://www.northwestern.edu/univ-relations/media_relations/releases/2005/01/oleic.html
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Products mentioned in this article:
MRP LoCarb (Vanilla or Chocolate)
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